Wyle left the series at the end of the eleventh season, although he returned in guest appearances for a four-episode arc during the twelfth season.He stated that he left because he wanted to spend more time with his family and friends and to make room for the upcoming generation.with three children of his own from a previous marriage.Wyle's paternal grandparents, Edith and Frank Wyle, founded the Los Angeles Craft and Folk Art Museum, and his grandfather also founded Wyle Laboratories.
In 1993 he appeared in another feature film, There Goes My Baby.
Kenneth Monnitoff in Donnie Darko (2001), and Flynn Carsen in The Librarian franchise.
Wyle was named one of the 50 Most Beautiful People by People magazine in 2001.
He was the youngest member when he joined the cast.
Wyle was the only major cast member of ER to have been with the show since its inception (1994) when he left after its eleventh season (2005).